Human gnome project.
This one came to my attention whilst perusing the slush pile at the publishing house I worked at for awhile. The guy was writing a very serious book on the Human Genome Project, and that typo was in his first sentence.
If it were in some far back page of the manuscript, I could forgive it. But the first sentence of the first paragraph of the first page? C'mon.
I'll give him points for letting the manuscript stick in my head, though I don't think we ended up publishing it.